Applied Pharmacology 7, Drug dose calculations

Applied Pharmacology 7, Drug dose calculations

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50 Comments

  1. Promise John on August 6, 2021 at 9:03 pm

    God bless you sir,looking forward to be a nurse.



  2. Tomasz Falkowski on August 6, 2021 at 9:04 pm

    This is the best video I’ve seen on Youtube and can you make a video on IV dose calculations?



  3. Gwen Maxwell on August 6, 2021 at 9:05 pm

    OMG, this made things so crystal clear for me!!! Thank you so much!



  4. Emelda Njuafack on August 6, 2021 at 9:05 pm

    Simple and easy to understand thank you very much sir



  5. bad boy on August 6, 2021 at 9:07 pm

    Uu



  6. hodan a on August 6, 2021 at 9:11 pm

    Thank you. You saved my life today. I work in busy medicine unit



  7. Theo Eze on August 6, 2021 at 9:12 pm

    Very helpful. Thanks



  8. Nasin Pa on August 6, 2021 at 9:12 pm

    May you tell me how 50 mg = 2mls in the first place ? πŸ™



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  10. malak khaled on August 6, 2021 at 9:13 pm

    Thank you so much drπŸ’—πŸ’—πŸ’—πŸ’—πŸ’—πŸ’—πŸ’—πŸ’—



  11. arm freelancer on August 6, 2021 at 9:18 pm

    A lot of thanks like million times



  12. Hannah Ferguson on August 6, 2021 at 9:20 pm

    Thank you for explaining this in a way that is easy to understand! I have to say I was mesmerised by the way you write your ‘g’s for some reason lol



  13. Just Me on August 6, 2021 at 9:21 pm

    Indeed! Thank you. πŸ‘‹



  14. Holly Jones on August 6, 2021 at 9:21 pm

    Great video, has helped so much! Thank you.



  15. Muno Abubakar on August 6, 2021 at 9:22 pm

    Thanks 😊 you sir this means alot for us πŸ‘



  16. The Sheriff Show - TSS on August 6, 2021 at 9:22 pm

    Thank you so much for this informative lecture. I really appreciate it. May God bless you.



  17. guli kaay on August 6, 2021 at 9:25 pm

    Hey doctor. Thank you for your videos. We are not allowed a calculator for our exams as nursing students πŸ₯²



  18. Claire Meus on August 6, 2021 at 9:26 pm

    Bro helpful



  19. Ahmed AbuAli on August 6, 2021 at 9:27 pm

    Dear Professor,

    I am trying to implement the work done by Suyu Liu, β€œA Bayesian Phase I/II Trial Design for Immunotherapy”, using R, since the code attached with that work takes a lot of time (more than 20 hours and the code not complete, I do not know how it produced the tables and the figures).

    So that I tried to use trialr package trying to get similar or approximate results using the utility functions for sensitivity analysis in table 1 (picture below), but this package allowed me to use just two outcomes ( toxicity, efficacy ) and the work of Liu used three outcomes (immune response, toxicity, and efficacy). I want to see if I used the correct utility (table 1 below) and to see how to add a third outcome ( immune response ) to the model? (Question 1)

    I attached to you the code and the output for 50 iterations and 60 patients from the work of Liu and Yuan ( I cannot do more, it took around 12 hours), if you know how he produced the results, (Question 2) I hope you can feed me back.

    My goal is: to use their idea to select the best dose in the first stage and to continue in a second stage with only 2 arms clinical trial and the best dose. (may there is another way to do that?)

    Table 1

    ### My code trying to get similar results using trialr package ###
    rm(list = ls())
    library(trialr)

    ## Utility from table 1 and Liu and Yuan work.

    Uti <- array(0,c(2,3,2)) # order: tox, eff, immuno
    Uti[,,1] <- matrix(c(0,0,50,10,80,35),nrow=2)
    Uti[,,2] <- matrix(c(5,0,70,20,100,45),nrow=2)

    N.max= 60 # patients

    outcomes <- ‘1NNN 2NNT 3NNT 4NNN 5NTN’
    doses = c(.1,.3,.5,.7,.9)

    fit <- stan_efftox(outcomes,
    real_doses =doses,
    efficacy_hurdle = 0.5, toxicity_hurdle = 0.3,
    p_e = 0.1, p_t = 0.1,
    eff0 = 0.5, tox1 = 0.65,
    eff_star = 0.7, tox_star = 0.25,
    alpha_mean = -7.9593, alpha_sd = 3.5487,
    beta_mean = 1.5482, beta_sd = 3.5018,
    gamma_mean = 0.7367, gamma_sd = 2.5423,
    zeta_mean = 3.4181, zeta_sd = 2.4406,
    eta_mean = 0, eta_sd = 0.2,
    psi_mean = 0, psi_sd = 1,
    seed = 123)

    ndoses <- length(fit$prob_tox)
    plot(1:ndoses, fit$prob_tox, type="b", pch=19, xlab="Dose level", ylab="Probability of toxicity", ylim=c(0,max(fit$prob_tox) + 0.15), col="green")
    points(1:ndoses,fit$prob_eff, type="b", pch=18, col="blue")
    abline(h=0.3, lwd=2, lty=4, col = "red")
    legend(1, 0.4, legend=c("Toxicity", "Effecacy"),
    col=c("green", "blue"), lty=1:2, cex=0.8)

    this produce this figure

    could you help me even by the paid consultancy?

    Thanks in advance



  20. Rola Ghannam on August 6, 2021 at 9:28 pm

    Thank you for this video! You made it so clear and easy to understand. God bless you.



  21. RealKingScrubs12 on August 6, 2021 at 9:28 pm

    even though i am to young to be learning this i want to be a teacher when i am older so i decided to search up some medical maths and try to learn a bit so hopefully this help me a bit



  22. Edyta Ed on August 6, 2021 at 9:28 pm

    Thank you Dr. Campbell



  23. atanga Sydiene on August 6, 2021 at 9:30 pm

    Thanks for this



  24. Jo on August 6, 2021 at 9:30 pm

    Dear Dr Campbell, As an old school lass going back into nursing, thank you for explaining why I do not like the formula as I kept saying… it doesnt feel right I cannot see it! Thank you



  25. Soumia Moujane on August 6, 2021 at 9:33 pm

    I am taking 100mg Lacosamide epilepsy tablets twice a day. My gp has put the quantity as 114. There is 14 in a pack. How is that worked out please?.



  26. catirerubio on August 6, 2021 at 9:33 pm

    Just when I think I have it, it gets scrambled in my mind. I salute all medical personnel that can carry this information and formulas in their heads. It is almost impossible, for me, on paper.



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  29. Kutu 12 on August 6, 2021 at 9:33 pm

    If my patient is 7 years old n 22kg .i want to prescribe syrup pcm 125mg .. How much ml sud i give to my pt.. ?



  30. CherryPiChick on August 6, 2021 at 9:34 pm

    COOL! I AM a mathematician and your 1st method is how The Ancient Egyptians did Multiplication. BRAVO! πŸ‘πŸ»πŸ’Š
    I showed this method to my students yesterday! 😁

    Also that calculator is SOOOO GREAT! Well built and long lasting…not the Crap Calculators they make in China these days. Is it made in Japan? Germany? Love the pen too. πŸ–‹β€οΈ Flo Nightingale would be proud! πŸͺ”

    I will be asking my students to watch your videos…Thanks Mate! πŸ€“πŸ’ŠπŸ’ŠπŸ’ŠπŸ’ŠπŸ’ŠπŸ’Š



  31. Anshuka Dakhole on August 6, 2021 at 9:36 pm

    πŸ‘



  32. glen Griffiths on August 6, 2021 at 9:38 pm

    Hi John, I need to get in touch with you as you touched on something extremely significantin this video that applies bang up to date – do you have a contact form so that I might contact you please regards glen griffiths @griffglen



  33. Lamrana Jalloh on August 6, 2021 at 9:38 pm

    Thank you sir.I have really learnt a lot



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    Yang milih allah like yg Mili dajal hirawkan 1:39………m



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  36. Tinashe Maka on August 6, 2021 at 9:42 pm

    Sir this is awesome. I.m out of any Pharmaceutical calculation exam TROUBLE now❀



  37. Nic Eagle on August 6, 2021 at 9:46 pm

    Whats the meaning of mls?



  38. Melissa Young on August 6, 2021 at 9:46 pm

    This Dr is So Amazing and when he’s explains it I really understand what steps to take to get my answer !



  39. Paulette Gayle on August 6, 2021 at 9:48 pm

    Great job!!



  40. L Mcmoney on August 6, 2021 at 9:48 pm

    Why do u not work out how many mg are in mls? E.g. 50mg in 2ml is 50Γ·2=0.04 then multiply by what you want 60=2.4? This is the way I’ve always worked out… obviously with a calculator. Once you know what the mg is per ml then you can do any dosage



  41. krutesh patel on August 6, 2021 at 9:49 pm

    in your video you have shown the calculation for pethidine instead of prednisolone, and thanks for such any easy methods for dose calculation.



  42. hulya Neben on August 6, 2021 at 9:51 pm

    Dr.John, can you please open a online Pharmacology class please. I will love to attend it.



  43. Cary BogΓ±albal on August 6, 2021 at 9:54 pm

    A patient is prescribed 2.5mg-5mg of morphine sulphate. You draw up 10mg of morphine sulphate and dilute it with 9ml 0.9% sodium chloride. The total volume is 10ml.
    How many mg does each ml contain?



  44. Medhat M. Moustafa on August 6, 2021 at 9:54 pm

    A 2- ml vial contains 50 mg pethidine. If we want give a patient a dose of 60 mg , how many mls would be given??
    We can cross multiply:
    2 ml gives>>>50 mg pethidine
    ? ??ml >>>>>>60 mg.
    60mg Γ— 2ml
    _____________ = 2.4 ml.
    50 mg



  45. Amanda W on August 6, 2021 at 9:57 pm

    Awesome , the what you want over what you have got x what’s it’s in is the easier method when working on a busy acute medical ward as a nurse πŸ‘©β€βš•οΈπŸ˜€. Still requires a 2 nurse check though to avoid drug errors . Like to revisit drug calcs though often to refresh my brain .



  46. Aminah Hussain on August 6, 2021 at 9:58 pm

    Thank you so much for taking the time out to make this video. It was incredibly simple to follow and well explained!



  47. RiseOfKilling on August 6, 2021 at 9:58 pm

    I love you



  48. shalini chaudhury on August 6, 2021 at 9:59 pm

    A SR TABLET DELIVER 10 MG OF DRUG EVERY HOUR THE %OF DRUG TO B RELEASED IN 300 MG TABLET AFTER 6 HOURS



  49. Sahil Ukhare on August 6, 2021 at 9:59 pm

    Great teaching techniques .. Thank you so much ❣️



  50. Muhammad Yaseen Mahtaab on August 6, 2021 at 10:01 pm

    Thank you…