# Applied Pharmacology 7, Drug dose calculations

Applied Pharmacology 7, Drug dose calculations

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Look, this video is not for casual viewing, its for people who are serious about professional health care. This is the same sort of lecture you could expect at during any university course, but this one is free. Health care should be off the people; for the people; by the people.

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Thank you!

God bless you sir,looking forward to be a nurse.

This is the best video I’ve seen on Youtube and can you make a video on IV dose calculations?

OMG, this made things so crystal clear for me!!! Thank you so much!

Simple and easy to understand thank you very much sir

Uu

Thank you. You saved my life today. I work in busy medicine unit

Very helpful. Thanks

May you tell me how 50 mg = 2mls in the first place ? π

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A lot of thanks like million times

Thank you for explaining this in a way that is easy to understand! I have to say I was mesmerised by the way you write your ‘g’s for some reason lol

Indeed! Thank you. π

Great video, has helped so much! Thank you.

Thanks π you sir this means alot for us π

Thank you so much for this informative lecture. I really appreciate it. May God bless you.

Hey doctor. Thank you for your videos. We are not allowed a calculator for our exams as nursing students π₯²

Bro helpful

Dear Professor,

I am trying to implement the work done by Suyu Liu, βA Bayesian Phase I/II Trial Design for Immunotherapyβ, using R, since the code attached with that work takes a lot of time (more than 20 hours and the code not complete, I do not know how it produced the tables and the figures).

So that I tried to use trialr package trying to get similar or approximate results using the utility functions for sensitivity analysis in table 1 (picture below), but this package allowed me to use just two outcomes ( toxicity, efficacy ) and the work of Liu used three outcomes (immune response, toxicity, and efficacy). I want to see if I used the correct utility (table 1 below) and to see how to add a third outcome ( immune response ) to the model? (Question 1)

I attached to you the code and the output for 50 iterations and 60 patients from the work of Liu and Yuan ( I cannot do more, it took around 12 hours), if you know how he produced the results, (Question 2) I hope you can feed me back.

My goal is: to use their idea to select the best dose in the first stage and to continue in a second stage with only 2 arms clinical trial and the best dose. (may there is another way to do that?)

Table 1

### My code trying to get similar results using trialr package ###

rm(list = ls())

library(trialr)

## Utility from table 1 and Liu and Yuan work.

Uti <- array(0,c(2,3,2)) # order: tox, eff, immuno

Uti[,,1] <- matrix(c(0,0,50,10,80,35),nrow=2)

Uti[,,2] <- matrix(c(5,0,70,20,100,45),nrow=2)

N.max= 60 # patients

outcomes <- ‘1NNN 2NNT 3NNT 4NNN 5NTN’

doses = c(.1,.3,.5,.7,.9)

fit <- stan_efftox(outcomes,

real_doses =doses,

efficacy_hurdle = 0.5, toxicity_hurdle = 0.3,

p_e = 0.1, p_t = 0.1,

eff0 = 0.5, tox1 = 0.65,

eff_star = 0.7, tox_star = 0.25,

alpha_mean = -7.9593, alpha_sd = 3.5487,

beta_mean = 1.5482, beta_sd = 3.5018,

gamma_mean = 0.7367, gamma_sd = 2.5423,

zeta_mean = 3.4181, zeta_sd = 2.4406,

eta_mean = 0, eta_sd = 0.2,

psi_mean = 0, psi_sd = 1,

seed = 123)

ndoses <- length(fit$prob_tox)

plot(1:ndoses, fit$prob_tox, type="b", pch=19, xlab="Dose level", ylab="Probability of toxicity", ylim=c(0,max(fit$prob_tox) + 0.15), col="green")

points(1:ndoses,fit$prob_eff, type="b", pch=18, col="blue")

abline(h=0.3, lwd=2, lty=4, col = "red")

legend(1, 0.4, legend=c("Toxicity", "Effecacy"),

col=c("green", "blue"), lty=1:2, cex=0.8)

this produce this figure

could you help me even by the paid consultancy?

Thanks in advance

Thank you for this video! You made it so clear and easy to understand. God bless you.

even though i am to young to be learning this i want to be a teacher when i am older so i decided to search up some medical maths and try to learn a bit so hopefully this help me a bit

Thank you Dr. Campbell

Thanks for this

Dear Dr Campbell, As an old school lass going back into nursing, thank you for explaining why I do not like the formula as I kept saying… it doesnt feel right I cannot see it! Thank you

I am taking 100mg Lacosamide epilepsy tablets twice a day. My gp has put the quantity as 114. There is 14 in a pack. How is that worked out please?.

Just when I think I have it, it gets scrambled in my mind. I salute all medical personnel that can carry this information and formulas in their heads. It is almost impossible, for me, on paper.

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If my patient is 7 years old n 22kg .i want to prescribe syrup pcm 125mg .. How much ml sud i give to my pt.. ?

COOL! I AM a mathematician and your 1st method is how The Ancient Egyptians did Multiplication. BRAVO! ππ»π

I showed this method to my students yesterday! π

Also that calculator is SOOOO GREAT! Well built and long lasting…not the Crap Calculators they make in China these days. Is it made in Japan? Germany? Love the pen too. πβ€οΈ Flo Nightingale would be proud! πͺ

I will be asking my students to watch your videos…Thanks Mate! π€ππππππ

π

Hi John, I need to get in touch with you as you touched on something extremely significantin this video that applies bang up to date – do you have a contact form so that I might contact you please regards glen griffiths @griffglen

Thank you sir.I have really learnt a lot

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Sir this is awesome. I.m out of any Pharmaceutical calculation exam TROUBLE nowβ€

Whats the meaning of mls?

This Dr is So Amazing and when he’s explains it I really understand what steps to take to get my answer !

Great job!!

Why do u not work out how many mg are in mls? E.g. 50mg in 2ml is 50Γ·2=0.04 then multiply by what you want 60=2.4? This is the way I’ve always worked out… obviously with a calculator. Once you know what the mg is per ml then you can do any dosage

in your video you have shown the calculation for pethidine instead of prednisolone, and thanks for such any easy methods for dose calculation.

Dr.John, can you please open a online Pharmacology class please. I will love to attend it.

A patient is prescribed 2.5mg-5mg of morphine sulphate. You draw up 10mg of morphine sulphate and dilute it with 9ml 0.9% sodium chloride. The total volume is 10ml.

How many mg does each ml contain?

A 2- ml vial contains 50 mg pethidine. If we want give a patient a dose of 60 mg , how many mls would be given??

We can cross multiply:

2 ml gives>>>50 mg pethidine

? ??ml >>>>>>60 mg.

60mg Γ 2ml

_____________ = 2.4 ml.

50 mg

Awesome , the what you want over what you have got x whatβs itβs in is the easier method when working on a busy acute medical ward as a nurse π©ββοΈπ. Still requires a 2 nurse check though to avoid drug errors . Like to revisit drug calcs though often to refresh my brain .

Thank you so much for taking the time out to make this video. It was incredibly simple to follow and well explained!

I love you

A SR TABLET DELIVER 10 MG OF DRUG EVERY HOUR THE %OF DRUG TO B RELEASED IN 300 MG TABLET AFTER 6 HOURS

Great teaching techniques .. Thank you so much β£οΈ

Thank you…